Psilocybin-containing mushrooms have been used in sacred rituals and ceremonies by various indigenous cultures for centuries. Here are a few examples:

Mesoamerican Cultures (Aztecs and Maya): Psilocybin mushrooms have a long history of use in Mesoamerican cultures. The Aztecs referred to them as teonanácatl, meaning "flesh of the gods." They were considered sacred and were used in religious ceremonies to induce altered states of consciousness, connect with the divine, and gain insights. The Maya are also believed to have used psychedelic mushrooms in their rituals.

Mazatec Culture (Oaxaca, Mexico): The Mazatec people of Oaxaca, Mexico, have a rich tradition of using psilocybin mushrooms, particularly the species Psilocybe cubensis. María Sabina, a Mazatec curandera (healer), gained international recognition for her role in introducing Westerners to the ceremonial use of psilocybin mushrooms.

Indigenous Peoples of Central Africa: Some indigenous groups in Central Africa have used psilocybin-containing mushrooms in their spiritual and healing practices. The use of these mushrooms has been documented among the Bwiti religion in Gabon, where they play a role in initiation ceremonies.

Ancient European Cultures: Some theories suggest that certain ancient European cultures may have used psychedelic mushrooms in their rituals (Amanita muscaria). However, direct historical evidence is limited.